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Povidone iodine (eye drops)
Available Brands 1.MICRODINE DPS.

Indications

As antiseptics
1. To prevent blindness
2. Pre-operative
3. Post-operative
4. Prevention of Ophthalmia Neonatorum pediatric conjunctivitis


Dosage

Pre-operative: (endophthalmitis): 1 - 2 drop of 5% Povidone-iodine ophthalmic solution on the eye before surgery. (Prior to Cataract Surgery, it must be administered after the local anaesthetic)
Post-operative: 2.5% Povidone-iodine solution placed on the eye immediately at the completion of the operation
Prevention of Ophthalmia Neonatorum: Povidone-iodine 2.5 % ophthalmic solution is used.
Pediatric conjunctivitis: Povidone-iodine 1.25% ophthalmic solution, applied 4times daily,
Chlamydial conjunctivitis, viral conjunctivitis:. Povidone-iodine 1.25% ophthalmic solution is used


Missed Dose

Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.


Overdose

Give supportive measures and symptomatic treatment.


Storage

Store at room temperature. Protect from heat and light. Keep out of the reach of children


Adverse Effects

Transient stinging,
Stronger than 0.5% icauses:
1.severe stinging
2.Hyperemia
3.Lacrimation.


Action Mechanism

Povidone iodine is an iodophore antiseptic and is a microbicidal drug. It releases iodine from its complex and produces pharmacological actions. The released iodine produces antiseptic actions. Iodine is highly reactive with surrounding and has strong oxidizing effect on functional groups of amino acids (-NH 2, -SH etc.), Nucleotides, and fatty acids (double bond of unsaturated fatty acids). Interaction of Iodine with these groups in a cell results in disintegration of the cytoplasm, enzyme denaturation, loss of integrity in the bacterial cell membrane and fungal cell wall. These will leads to destruction of microbial protein and DNA and finally kill the microbes The Ocular Application of Povidone-Iodine Agents like Povidone additionally mimic the action of mucin, the inner tear film layer that promotes wetting and adhesion of tears to the ocular surface
It has a very broad antimicrobial spectrum, including bacteria, viruses, and fungi. Resistance by bacteria is rare. It is not expensive


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